Session: Making sense of uninformative test results

Speaker: Rebecca Sutphen, MD

This 90-minute concurrent session will focus on individuals and families that have
tested with a BRCA variant or uninformation negative test but still have
hereditary cancer in the family. Dr. Sutphen will present :

• types of inconclusive BRCA test results and what they may mean
• the limitations of BRCA testing and what percent of negative families may still have BRCA mutations
• the differences between variants, uninformative negative tests, and true negatives
• breast and ovarian cancer risk in families with familial breast cancer only
• other hereditary syndromes that may account for cancer in BRCA-negative families
• low-penetrant genes, SNPs, and multiplex tests that may explain cancer in BRCA negative families
• other, nonhereditary causes of cancer in families
  

This session is appropriate for:

• people who have tested with a BRCA variant result
• people with an uninformative negative BRCA result
• people whose families have history of breast or ovarian cancer but no known BRCA mutation
• spouses, partners, and significant others of people with an uninformative negative BRCA result
• health care providers who provide care to people with hereditary cancer
• social workers/mental health care professionals who treat people with hereditary cancer
  

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