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Sign Up for FORCE NewslettersInformation for People with Inherited MUTYH Mutations
People who inherit mutations in both copies of their MUTYH gene have MUTYH-associated polyposis (MAP). People with MAP are at high risk for several types of cancer, beginning at a young age.
People with a mutation in only one copy of their MUTYH gene do not develop MAP. These people have a slightly increased risk for colorectal cancer.
There are guidelines for screening and prevention for certain cancers in people with MAP and for people with a single MUTYH mutation.
People with MAP who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Because of the high lifetime risk of cancer, people with MAP of reproductive age may wish to speak with a genetics expert about options related to family planning.
Each of these topics is outlined in more detail in the sections highlighted below.
Community Stories
More Information on MUTYH Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited MUTYH mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with MUTYH mutations. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with a MUTYH mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
Because of the high lifetime risk of cancer with MAP, people with a MUTYH mutation of reproductive age may wish to speak with a genetics expert to discuss carrier screening for their partner, prior to having children.
More Resources
View Our Expert Webinars
Webinar: Colorectal Cancer Screening and Prevention in High-Risk Individuals
Webinar: What's New in Colorectal Cancer Treatment?