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Sign Up for FORCE NewslettersInformation for People with Inherited Mutations
mutations are linked to a condition known as . People with an in have a very high lifetime risk for different types of cancers, including:
- breast cancer
- endometrial cancer
- kidney cancer
- thyroid cancer
- colorectal cancer
- other cancers
There are expert guidelines with recommendations for screening and prevention of these cancers.
People with an inherited mutation who have been diagnosed with cancer may also qualify for specific treatment or clinical trials. This includes a new type of known as an AKT inhibitor that was just approved for treating breast cancer in people with mutations in their tumor. Treatment clinical trials are enrolling people with TPEN mutations.
Some mutations in cause or Bannayan-Riley-Ruvalcaba syndrome. Together these syndromes are known as Hamartoma Tumor syndrome (PHTS). There may be other medical concerns for people with a mutation, including cancer risks for children beginning at a young age.
Each of these topics is outlined in more detail in the sections highlighted below.
In the News
Participate in Research
To search for more studies, visit our Search and Enroll Tool.
Clinicaltrials.gov identifier:
NCT04042831
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
mutations are linked to , which can cause medical conditions beyond cancer. Learn about other important considerations for people with inherited mutations.